KS was first described in 1942 as an endocrine disorder.5. What are the treatments for symptoms in Klinefelter syndrome (KS)? However, new studies have found that with the help of assisted reproductive therapy, some individuals with Klinefelter Syndrome can father children. Klinefelter's Syndrome Treatment This syndrome is non-curable; however there are available treatments to cure the symptoms brought by Klinefelter's syndrome. Drugs used to treat Klinefelter Syndrome The following list of medications are in some way related to, or used in the treatment … Men with Klinefelter’s Syndrome also have treatments for enlarged breasts and infertility. Blood or urine samples can reveal abnormal hormone levels that are a sign of Klinefelter syndrome. Cases where three or more X chromosomes are present are much less common, affecting just 1 in 50,000 newborn males. What is a Haplotype? Additionally, individuals are at an increased risk for breast cancer, lung disease, and varicose veins. Most individuals with this condition will lead healthy and meaningful lives. Advances in assistive reproductive technology (ART) have made it possible for some men with KS to conceive. Endodontic treatment in three taurodontic teeth associated with 48,XXXY Klinefelter syndrome: A review and case report. It’s a question that many men ask after being diagnosed. While there is no cure for sex chromosome changes caused by Klinefelter syndrome, treatments can help minimize effects, especially when … It occurs when a male baby is born with more than required or extra X chromosomes. If treatment is needed, it’s recommended that they begin as early as possible, preferably during puberty or childhood. Treatment List for Klinefelter syndrome. Some may develop anxiety, depression, behavioral problems, or experience difficulty with social skills or attention. Klinefelter syndrome treatment. For males whose testosterone level is low to normal, the benefits of taking testosterone are less clear than for when testosterone is very low. However, more recent research estimates that life expectancy is shortened by only 2 years 4. Management of Klinefelter Syndrome: The management of Klinefelter syndrome in the Allopathy medicine system is done with Psychological counseling, Fertility treatment, Breast tissue removal, and Testosterone replacement therapy. Klinefelter syndrome is a genetic condition that affects males. The primary features are infertility and small poorly functioning testicles. But this type of treatment is not suitable because surgery causes greater pain and also costs higher. This treatment should begin at puberty or as soon after as possible. … Breast Tissue Removal. Klinefelter syndrome (sometimes called Klinefelter's, KS or XXY) is where boys and men are born with an extra X chromosome. The only study which shows clear association between gynecomastia and male breast cancer is with Klinefelter syndrome; patients who have gynecomastia and Klinefelter syndrome are at about 50% increased risk of male breast cancer. Klinefelter syndrome may affect up to 1 in 500 male births in the world today.2. Luckily, the treatment options noted above can greatly improve quality of life and prevent some complications from occurring. Individuals with this condition are also at an increased risk to develop autoimmune disorders such as rheumatoid arthritis, systemic lupus, and Sjogren Syndrome. General practitioners. Mitral valve prolapse tends to occur more commonly in individuals with Klinefelter Syndrome than those without, however this heart condition may pose no medical problems, or it could be severe enough to require surgery. It is important to know that your genes are not your destiny. In adolescence, symptoms such as lack of body hair could make XXY males uncomfortable in school or other social settings, and this discomfort can lead to depression, substance abuse, and behavioral problems or "acting out." They might also have questions about their masculinity or gender identity.9 In these instances, consulting a psychologist, counselor, or psychiatrist may be helpful. There is a large community of families with this condition who can provide guidance and support. Individuals with this condition should see endocrinology to discuss testosterone therapy. The primary feature is sterility. Klinefelter Syndrome Treatment. Because these tests come with a small risk of miscarriage, their use is very conservative. Males with Klinefelter syndrome should be seen by a team of health care providers. The information on this website is not to be used as a substitute for medical advice, diagnosis, and/or treatment. There is evidence that indicates women who give birth over the age of 35 are slightly more likely to have a son with Klinefelter syndrome. People typically have 46 chromosomes in each cell, two of which are the sex chromosomes. Psychologists and/or psychiatrists. Klinefelter syndrome treatment. NIH staff guidance on coronavirus (NIH Only): https://employees.nih.gov/pages/coronavirus/, It's important to remember that because symptoms can be mild, many males with KS are never diagnosed ore treated.1. Treatments for Klinefelter syndrome. One of these is through testosterone treatment. There are genetic tests that can diagnose Klinefelter syndrome. This could mean their sex chromosomes could be XXY, XXXY, XXXXY, or something along those lines. Coming soon! For instance, it is possible that the resulting child might have the XXY condition. Assisted reproductive technology (ART) procedures can help some men with Klinefelter syndrome overcome infertility issues. It’s commonly used to treat depression and anxiety. That's why we've done the research. In many cases, men with Klinefelter syndrome can’t father a child naturally on their own. For example, guys with Klinefelter syndrome may be more likely to get some types of cancer and other diseases, like type 2 diabetes and osteoporosis, a condition where the bones become weaker later in life. This is one of the most common Klinefelter syndrome treatments since many of the symptoms stem from low testosterone. Importantly, there is no guarantee the procedure will work. Due poor or no sperm count, the majority of the men with Klinefelter syndrome are found to be infertile. 1. Speech therapy should be started as soon as possible to maximize its effectiveness. Connect with our licensed genetic counselors now. Treating Social and Behavioral Symptoms. There are treatment options to help men overcome the obstacles of low sperm count, but they are not always successful. Not all males with XXY condition benefit from testosterone therapy. We take the information we share seriously. About one-half of XXY males' chromosomes have low testosterone levels.4 These levels can be raised by taking supplemental testosterone. Although the majority of boys with KS grow up to live as males, some develop atypical gender identities. Review our Editorial Policy Here. Men who have enlarged breasts are at an increased risk of getting breast cancer. In about 10% of cases, only some of the cells have an extra X chromosome, this is said to be mosaic Klinefelter Syndrome, and it tends to have milder symptoms. For these males, supplemental testosterone may not be suitable. When a diagnosis is made, treatment is based on the signs and symptoms present in each person, especially the problems related to hypogonadism, gynecomastia, and psychosocial problems. With regard to education, some boys with KS will qualify to receive state-sponsored special needs services to address their developmental and learning symptoms. Testosterone; Educational support - for language difficulties. L'individu est alors de caractère masculin, mais infertile. A recent Danish study indicated that Klinfelter syndrome was present in 153 per 100,000 babies tested.3. Treatment Options for Klinefelter Syndrome . Your doctor will likely do a thorough physical exam and ask detailed questions about symptoms and health. Treatment can help males overcome many of the physical, social, and learning problems that are part of the syndrome. However, treatment can bring benefits at any age. The American Society of Plastic Surgeons’ 2018 Plastic Surgery Statistics notes that gynecomastia (breast reduction in men) increased 22% since 2000 with 24,753 procedures being performed in 2018. There is a study that claims that timely and planned support allotted to young men with this condition can restore present poor psychosocial effects. Learn more about Klinefelter syndrome, including how it affects men's hormone health and what treatment options are available. Hormone testing. While ART procedures have improved in recent years, there’s still no guarantee they will work. But various interventions, such as speech therapy and educational assistance, can help to reduce and even eliminate these difficulties. Klinefelter syndrome: Is the Diagnosis Correct? Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontolog y , 105 (5), 670-677. Chorionic Villus Sampling (CVS) - This test is done during pregnancy to identify possible chromosomal abnormalities. The primary features are infertility and small poorly functioning testicles. Always seek professional medical advice about any treatment or change in treatment plans. Overview of Klinefelter Syndrome, 47,XXY. Specifically, infertility is due to a low sperm count or a complete lack of sperm. ; About one of every 500 males has an extra X chromosome, but many don't have any symptoms. Fertility Treatment. Klinefelter syndrome is one of the most common chromosomal disorders, affecting 1/500 to 1/1,000 newborn males. Klinefelter syndrome is a fairly common genetic condition found in males only.. Read our guide here. We want you to have one resource to turn to for facts presented in such a way that they are easy to understand. Upwards of 75% of children with it have a learning disability. Analysis of 25 years of studies involving 466 men with Klinefelter syndrome found that patients had a 50% higher mortality rate 3 and their life expectancy was 5 years shorter than average. For others, it can be difficult to cope with the side effects, especially during adolescence. Because symptoms of Klinefelter syndrome (KS) can sometimes be very mild, many people are never diagnosed or treated. Read More...We will do our best to keep our content current, but it's important to know the new research can change our content at any time. However, these symptoms do not occur in everyone with this condition. Klinefelter syndrome may affect up to 1 in 500 male births in the world today.2. 1. One of these is through testosterone treatment. There is a study that claims that timely and planned support allotted to young men with this condition can restore present poor psychosocial effects. Genetic counselors play a vital role in the process of understanding your test results. 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Learn more about the causes, symptoms, and treatment of Klinefelter syndrome. Chromosomes are packages of genes found in every cell in the body. These tests are also known as "direct-to-consumer genetic tests". Klinefelter is a genetic disorder that affects males; this is due to when a male born with an extra copy of X chromosome, which causes infertility, low testosterone and other abnormalities such as breast development. A recent Danish study indicated that Klinfelter syndrome was present in 153 per 100,000 babies tested.3. Most males have one Y and one X chromosome. The odds may be improved by freezing sperm in adolescence when the sperm is healthier. They include: As boys get older they may also find that they have a low or decreased sex drive. An estimated 53-55% of conceptions affected with Klinefelter syndrome are expected to survive to term.4. Individuals with this condition might have lower self-esteem than their peers and need additional emotional support. 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