View abstract. View abstract. Chanca piedra might have an effect like a water pill or "diuretic." Asian Pac.J Trop.Med 2011;4(4):283-287. Find it in foods like potatoes, beet greens, avocados and spinach. Bhattacharyya R, Bhattacharya S. Development of a potent in vitro source of Phyllanthus amarus roots with pronounced activity against surface antigen of the hepatitis B virus. Ott, M., Thyagarajan, S. P., and Gupta, S. Phyllanthus amarus suppresses hepatitis B virus by interrupting interactions between HBV enhancer I and cellular transcription factors. Drink cranberry juice.
Singh, M., Tiwari, N., Shanker, K., Verma, R. K., Gupta, A. K., and Gupta, M. M. Two new lignans from Phyllanthus amarus. Chanca piedra may increase the excretion of electrolytes like potassium. However, even if supplements are third-party tested, that doesn't mean they are safe for all or effective in general. J Ethnopharmacol. 2018 Jul-Aug; 44(4): 758764. Antiviral Res 2003;58(2):175-186. Taking chanca piedra along with other "water pills" might cause the body to lose too much water. While this effect can help manage hyperglycemia (high blood sugar) in animals, more human studies are needed. 2006;29(1):177-179. What should I eat to lower the risk of uric acid stones? Stay on the safe side and avoid use. 2006;7(2):299-302. Okoli CO et al. Ajaiyeoba E, Kingston D. Cytotoxicity evaluation and isolation of a chroman derivative from Phyllanthus amarus aerial part extract. Amli, Arranca-Pedras, Bhonya, Bhoomi Amalaki, Bhui-Amla, Bhumi Amla, Bhuianvalah, Bhuimy Amali, Bhuin Amla, Bhumy Amalaki, Bhumyamalaki, Brise Pierre, Cane Peas Senna, Cane Senna, Carry-Me-Seed, Casse-Pierre, Chancapiedra, Chanca-Piedra Blanca, Chance Pierre, Child Pick-a-Back, Creole Senna, Daun Marisan, Derriere-Dos, Des Dos, Deye Do, Dukong Anak, Elrageig, Elrigeg, Erva-Pombinha, Evatbimi, Feuilles la Fièvre, Gale-Wind Grass, Graine En Bas Fièvre, Graine-En-Bas-Feuille, Hurricane Weed, Jar-Amla, Jar Amla, Kizha Nelli, Malva-Pedra, Mapatan, Memeniran, Meniran, Niruri, Nymphanthus niruri, Para-Parai Mi, Paraparai Mi, Pei, Phyllanto, Phyllanthus amarus, Phyllanthus carolinianus, Phyllanthus fraternus, Phyllanthus kirganella, Phyllanthus lathyroides, Phyllanthus lonphali, Phyllanthus niruri, Phyllanthus sellowianus, Pierre de Chanca, Pitirishi, Pombinha, Punarnava, Quebra Pedra, Quebrapedra, Quinina Criolla, Quinine Creole, Quinine Weed, Rami Buah, Sacha Foster, Sasha Foster, Seed on the Leaf, Semence dans la Feuille, Shka-Nin-Du, Shatter Stone, Stone Breaker, Stone-Breaker, Stonebreaker, Tamalaka, Turi Hutan, Viernes Santo, Ya-Taibai, Yaa Tai Bai, Yah-Tai-Bai, Yerba de San Pablo. Always speak with a healthcare provider before taking a supplement to ensure that the supplement and dosage are appropriate for your individual needs. Indian J Pharmacol. Mellinger, C. G., Carbonero, E. R., Cipriani, T. R., Gorin, P. A., and Iacomini, M. Xylans from the medicinal herb Phyllanthus niruri. on five vegetative organisms. Integr.Cancer Ther. View abstract. Dhianawaty DD, Padmawinata K Soediro I et al. Ann.Trop.Med Parasitol. You are encouraged to report negative side effects of prescription drugs to the FDA. Raintree tropical plant database, Amazon plants. Please review the supplement label with your healthcare provider to discuss potential interactions with foods, other supplements, and medications. View abstract. In test-tube studies, chanca piedra extract has killed the bacterium Helicobacter pylori, which causes stomach ulcers. The effect of Phyllanthus niruri on urinary inhibitors of calcium oxalate crystallization and other factors associated with renal stone formation. 11-1-2007;114(2):169-173. View abstract. Bioefficacy of Tinospora cordifolia and Phyllanthus niruri plants against Spodoptera litura (Fabricius) and Dysdercus koenigii (Fabricius). vitamins, herbs, dietary supplements a-z listchanca piedra. Devika R, Sajitha U. Phytochemical and pharmacological investigation of Phyllanthus niruri - a preliminary screening. 2005;68(10):1479-1483. One of the earliest studies of chanca piedra found that people who drank a traditionally brewed tea for 1 to 3 months had a significantly reduced rate of kidney stones. 2010;48(1):396-401. More research in humans is needed to support these claims. Asian Pac.J Cancer Prev. View abstract. Indian J Pathol.Microbiol. 4-Methoxy-nor-Securinine, a New Alkaloid from Phyllanthus niruri. View abstract. www.ars-grin.gov/duke (Accessed 3 November 1999). extract in ethanol treated rats: in vitro and in vivo studies. Chanca piedra has been used for kidney stones, hepatitis B, and digestive health. A prospective, randomised short term study [abstract no: 178] . Kumar, K. B. and Kuttan, R. Chemoprotective activity of an extract of Phyllanthus amarus against cyclophosphamide induced toxicity in mice. Taking chanca piedra along with diabetes medications might cause your blood sugar to go too low. In a clinical trial involving kidney stones, chanca piedra demonstrated the same effect. View abstract. J Nat.Prod. Effect of phyllanthus niruri on metabolic parameters of patients with kidney stone: a perspective for disease prevention. Studies on the possible mechanisms of antidiabetic activity of extract of aerial parts of Phyllanthus niruri.
We've updated our Privacy Policy, which will go in to effect on September 1, 2022. There isn't enough evidence from clinical research to show a precise, safe, and effective dose of chanca piedra. Indian J Biochem Biophys. The plant grows in the Amazon rainforest and other tropical areas of the world. It Could Be Your Adrenals, Tame The Flames: 6 Anti-Inflammatory Supplements, Feeling Sluggish and Low on Energy? 2003 Feb;30(6):374-9. Integr.Cancer Ther. Zhang JL, He WN Ye P. Clinic observation on Phyllanthus amarus for treating chronic HBV infection. View abstract. Agri Res Svc: Dr. Duke's phytochemical and ethnobotanical databases. Immunol.Invest 2010;39(3):245-267. Chanca piedra lowered urinary oxalate and uric acid (waste products that exit your body via urine). Is it possible to reduce the risk of getting calcium oxalate stones? View abstract. Banerjee A, Chattopadhyay S. Effect of over-expression of Linum usitatissimum PINORESINOL LARICIRESINOL REDUCTASE (LuPLR) gene in transgenic Phyllanthus amarus. Journal of Applied Sciences and Environmental Management 2009;37-41. 2010;36(6):657-64. doi:10.1590/s1677-55382010000600002, Lee NY, Khoo WK, Adnan MA, Mahalingam TP, Fernandez AR, Jeevaratnam K. The pharmacological potential of Phyllanthus niruri. Nworu, C. S., Akah, P. A., Okoye, F. B., and Esimone, C. O. Aqueous extract of Phyllanthus niruri (Euphorbiaceae) enhances the phenotypic and functional maturation of bone marrow-derived dendritic cells and their antigen-presentation function. Narendranathan, M., Remla, A., Mini, P. C., and Satheesh, P. A trial of Phyllanthus amarus in acute viral hepatitis. - an hepatoprotective plant. Luyindula, N, Tona, L, Lunkebila, S, Cimanga, RK, Vlietinck, AJ, and et al. View abstract. And senna and aloe contain anthraquinones, compounds that bind calcium and reduce the growth rate of urinary crystals. Murugaiyah, V. and Chan, K. L. Analysis of lignans from Phyllanthus niruri L. in plasma using a simple HPLC method with fluorescence detection and its application in a pharmacokinetic study. Planta Med 1991;57(1):98. Mazumder A, Mahato A Pattnaik AK et al. View abstract. View abstract. Histological effects of chronic administration of Phyllanthus amarus on the superior colliculus of adult wistar rats. Colombo, R., de, L. Batista AN, Teles, H. L., Silva, G. H., Bomfim, G. C., Burgos, R. C., Cavalheiro, A. J., da, Silva Bolzani, V, Silva, D. H., Pelicia, C. R., Guimaraes, F. M., and Heimberg, M. C. Validated HPLC method for the standardization of Phyllanthus niruri (herb and commercial extracts) using corilagin as a phytochemical marker. One health benefit of chanca piedra is that its antioxidants may improve fasting blood sugar levels in certain animals. Cancer Lett. Dosage: How Much Chanca Piedra Should I Take? There may be a disruption in electrolyte balance if too much chanca piedra is taken. Increase insulin activity by Phyllanthus amarus Linn on liver cell regeneration in partially hepatectomised albino rats. 10-8-2003;478(2-3):145-153. Journal of Natural Remedies 2001;1(1):55-59. Biomedical & Pharmacology 2010;123-128. Effect of extract of Phyllanthus niruri on crystal deposition in experimental urolithiasis.
Alvari A, Rafsanjani MS Ahmed FJ et al. African Journal of Biotechnology 2007;728-731. Kidney Stones: Treatment. Herbs of the genus Phyllanthus in the treatment of chronic hepatitis B: observations with three preparations from different geographic sites. When taken with water pills, chanca piedra could cause your blood pressure to be too low.Lithium: Chanca piedra may act as a diuretic (water pill), impacting how efficiently the body gets rid of lithium. View abstract. & Thonn. To prevent uric acid kidney stones, reduce the amount of meat, eggs, fish, and poultry you eat.
J Ethnopharmacol. Journal of Experimental Zoology 2003;6(1):151-156. View abstract. Antidiabetic medications (including insulin and oral medications such as DiaBeta, and Diabinese): Chanca piedra is thought to lower blood sugar levels. Journal of Essential Oil Research 2009;393-399. B., Antarkar, D. S., Deolalikar, R., and Antani, D. H. A two-stage clinical trial of Phyllanthus amarus in hepatitis B carriers: failure to eradicate the surface antigen.
In vitro study on alpha-amylase inhibitory activity of an Indian medicinal plant, Phyllanthus amarus. Faremi, T. Y., Suru, S. M., Fafunso, M. A., and Obioha, U. E. Hepatoprotective potentials of Phyllanthusamarus against ethanol-induced oxidative stress in rats. Wang LT, He Y Ren JW Jiang J et al. Annals of Biological Research 2011;298-305. Lancet 10-1-1988;2(8614):764-766. Abdulla MA, Ahmed KA Al-Bayaty FH et al. Phytochemistry 1996;43(3):715-717. View abstract. Journal of Applied Sciences and Environmental Management 2009;5-9. Asian Journal of Biotechnology 2009;154-162. 7-15-2009;124(2):233-239. Fitoterapia 1993;64(3):235-238. New seco- and hydroxy-lignans from Phyllanthus niruri. Soares LA, Bassani VL Ortega GG et al. Manjrekar, A. P., Jisha, V., Bag, P. P., Adhikary, B., Pai, M. M., Hegde, A., and Nandini, M. Effect of Phyllanthus niruri Linn. Avoid foods high in oxalates, compounds that occur naturally in many foods and are the basis for many kidney stones. For this reason, it's difficult for researchers to recommend one proper dosage to ensure safety and effectiveness. Biol.Pharm.Bull. Rapid RP-HPLC technique for the determination of phyllanthin as bulk and its quantification in Phyllanthus amarus extract. Phytochemistry 2008;69(3):759-764.
Ishimaru K, Yoshimatsu K Yamakawa T et al. Follow the package instructions for when to discard the supplement as well. View abstract. Akinnibosun, FJ Akinnibosun HA Ibeh IN et al.
Ali, H., Houghton, P. J., and Soumyanath, A. alpha-Amylase inhibitory activity of some Malaysian plants used to treat diabetes; with particular reference to Phyllanthus amarus. Innovative Food Science & Emerging Technologies 2010;526-532. Myanmar Health Sciences Research Journal 2009;17-21. Animal studies show that chanca piedra supplements may decrease uric acid levels in humans. et Thonn (Euphorbiaceae) against three species of mosquitoes. Chem Pharm.Bull. Eliminate refined sugar and high fructose corn syrup. Berk, L., de Man, R. A., Schalm, S. W., Labadie, R. P., and Heijtink, R. A. Excessive excretion of potassium can decrease potassium to unsafe levels, causing an electrolyte imbalance. Rajeshkumar, N. V., Joy, K. L., Kuttan, G., Ramsewak, R. S., Nair, M. G., and Kuttan, R. Antitumour and anticarcinogenic activity of Phyllanthus amarus extract. Krithika, R. and Verma, R. J. Ameliorative potential of Phyllanthus amarus against carbon tetrachloride-induced hepatotoxicity. In addition to the uses listed above, other traditional uses for chanca piedra include: However, studies haven't produced the kind of high-quality evidence needed to validate any digestive health claims at this time. and its protective mechanism on paracetamol hepatotoxicity in rats. Chemosphere 2005;61(11):1644-1650. Brook, M. G. Effect of Phyllanthus amarus on chronic carriers of hepatitis B virus. Chanca piedra is known by several names, including: The herb contains phytochemicals that may increase urine flow, destroy harmful bacteria and viruses, and reduce inflammation. 2005;12(6-7):494-500. Southeast Asian J Trop.Med Public Health 2007;38(4):609-615. Harvard Health Publication. View abstract. Vijayanand V, Nagarajan B Vasu K. Efficacy of Azadirachta indica and Phyllanthus amarus in experimental hepatitis in dogs. Molecular Medicine & Advance Sciences 2006;184-189. Studies on the possible mechanisms of antidiabetic activity of extract of aerial parts of Phyllanthus niruri. Zhu FM, Zhang JQ Zhang XZ et al. Barros, M. E., Lima, R., Mercuri, L. P., Matos, J. R., Schor, N., and Boim, M. A. National Institutes of Health. Evaluation of the levels of the lignans phyllanthin, hypophyllanthin and niranthin in "quebra-pedra" (Phyllanthus amarus Schumach. J-Clin-Epidemiol 1997;50(8S). Chanca piedra has been used for thousands of years to relieve pain, reduce muscle spasms and block inflammation. Taesotikul, T., Dumrongsakulchai, W., Wattanachai, N., Navinpipat, V., Somanabandhu, A., Tassaneeyakul, W., and Tassaneeyakul, W. Inhibitory effects of Phyllanthus amarus and its major lignans on human microsomal cytochrome P450 activities: evidence for CYP3A4 mechanism-based inhibition. Teratog.Carcinog.Mutagen. Pharmaceutical Biology 2006;44:668-671. Adeneye AA, Benebo AS Agbaje EO. Therapeutic observation of Phyllanthus amarus for treatment of hepatitis B . Freitas AM et al. Thidiazuron-induced shoot organogenesis and production of hepatoprotective lignan phyllanthin and hypophyllanthin in Phyllanthus amarus. under water deficit conditions. J Pharm Pharmacol. Food Chemistry 2009;1405-1412. The Anti-Inflammatory and Antinociceptive Properties of the Chloroform Fraction From Phyllanthus niruri Plant Is Mediated via the Peripheral Nervous System. View abstract. McHarg T et al. If theyre small enough, kidney stones can pass through the urinary tract on their own with no incident, but larger ones can cause enormous pain and serious complications. 2010 Jun;101(12):4676-89. Bionotes 2011;14-16. Venkateswaran, P. S., Millman, I., and Blumberg, B. S. Effects of an extract from Phyllanthus niruri on hepatitis B and woodchuck hepatitis viruses: in vitro and in vivo studies. View abstract. Andrew EO, Enogieru A. Chanca piedra may have interactions with herbal supplements exhibiting the same effects listed above, such as: It is essential to read the labels of supplements. Indian J Med Sci 2003;57(9):387-393.
Thyagarajan, S. P., Jayaram, S., Valliammai, T., Madanagopalan, N., Pal, V. G., and Jayaraman, K. Phyllanthus amarus and hepatitis B. Lancet 10-13-1990;336(8720):949-950. View abstract. 2008;13(5):199-207. Preventive effect of Phyllanthus amarus on prostatic hyperplasia. Exploring alternative treatments for Helicobacter pylori infection, Studies on the possible mechanisms of antidiabetic activity of extract of aerial parts of Phyllanthus niruri, Eating, diet, and nutrition for kidney stones, The kidney stone diet: Not as restricive as you may think, Infections (including sexually transmitted infections). Asian Journal of Experimental Sciences 2010; Bhattacharjee, R. and Sil, P. C. Protein Isolate from the Herb Phyllanthus niruri Modulates Carbon Tetrachloride-Induced Cytotoxicity in Hepatocytes. A 2014 study found that chanca piedra had antimicrobial activity (the ability to kill or prevent microbes) against Helicobacter pylori (H. pylori). 2011;22(4):361-366. 2014 Nov 28:1-22. Iizuka, T., Moriyama, H., and Nagai, M. Vasorelaxant effects of methyl brevifolincarboxylate from the leaves of Phyllanthus niruri. vitamins, herbs, dietary supplements a-z list. et Thonn. Londhe, J. S., Devasagayam, T. P., Foo, L. Y., and Ghaskadbi, S. S. Antioxidant activity of some polyphenol constituents of the medicinal plant Phyllanthus amarus Linn. Antibacterial effect of Phyllanthus niruri (Chanca Piedra) on three enteropathogens in man. Norepinephrine treats low blood pressure by causing blood vessels to constrict. Acta Pol.Pharm. Clinic study on chronic HBV infection treated by Phyllanthus amarus. Evaluation of antiinflammatory activity of methanol extract of Phyllanthus amarus in experimental animal models. L.Acta Farmaceutica Bonaerense 2003;33:203-207. As with all supplements and plant medicines, it's essential to discuss the use of chanca piedra with your healthcare provider before taking it. View abstract. By clicking Accept All Cookies, you agree to the storing of cookies on your device to enhance site navigation, analyze site usage, and assist in our marketing efforts. Indian J Exp.Biol. Int Braz J Urol. J Hepatol. J Ethnopharmacol. Journal of Medicinal and Aromatic Plant Sciences 1999;21(1):51. Houghton PJ, Woldemariam TZ O'Shea S et al. It was pointed out that these are also symptoms of kidney stones. Immunopharmacol.Immunotoxicol. A. and Benebo, A. S. Protective effect of the aqueous leaf and seed extract of Phyllanthus amarus on gentamicin and acetaminophen-induced nephrotoxic rats. View abstract. Plant Archives 2008;563-568. & Thonn.--a hepatoprotective herb. Side effects reported in one human study using a chanca piedra infusion included: Additional health risks of chanca piedra may include: Chanca piedra may lower blood sugar levels, which means it might affect blood sugar control during and after surgery. Next to red peppers, you can get the most vitamin C from ________________. Myint MM, Than MA Lwin KK et al. The pharmacological potential of Phyllanthus Niruri. 2006;29(7):1310-1313. BJU.Int. Vaccine 1990;8 Suppl:S86-S92. Etta HE, Udoh PB Asuquo BO et al. Srividya N et al. 2011;30(1):43-53. Murali B, Amit A Anand MS et al. Obidike IC, Salawu OA Ndukuba M et al. View abstract. International Journal of Phytomedicine 2011;115-119. Teramoto JR, Oliveira RF Santos AS et al.
Phytother.Res 2006;20(7):595-601. Chanca piedra supplements are available in powder, juice, or tea form. Thyagarajan, S. P., Subramanian, S., Thirunalasundari, T., Venkateswaran, P. S., and Blumberg, B. S. Effect of Phyllanthus amarus on chronic carriers of hepatitis B virus. This conversation is especially important if you have a health condition or are taking any medications, other plant medicines, or dietary supplements. Antimicrobial activity of an Amazon medicinal plant (Chancapiedra) (Phyllanthus niruri L.) against Helicobacter pylori and lactic acid bacteria. Fitoterapia 2006;77(7-8):511-514. Inositol hexaphosphate, a carbohydrate found in cereal grains, beans, brown rice and other high-fiber foods helps reduce urinary calcium levels, inhibit crystallization of calcium salts, and lower the risk of stones. Toxicol.Mech.Methods 2010;20(8):498-503. J Nat.Prod. 2017 Jul; 9(7): 766. View abstract. Boim, M. A., Heilberg, I. P., and Schor, N. Phyllanthus niruri as a promising alternative treatment for nephrolithiasis. View abstract. Pharm Biol. These agencies evaluate products and report on herbal and natural products' safety, purity, and potency. Sumathi, P Parvathi A. Antibacterial potential of Phyllanthus niruri L. Journal of Pure and Applied Microbiology 2011;425-428. Akin-Osanaiye CB, Gabriel AF Alebiosu RA. View abstract. Bhattacharjee, R. and Sil, P. C. The protein fraction of Phyllanthus niruri plays a protective role against acetaminophen induced hepatic disorder via its antioxidant properties. Kiemer, A. K., Hartung, T., Huber, C., and Vollmar, A. M. Phyllanthus amarus has anti-inflammatory potential by inhibition of iNOS, COX-2, and cytokines via the NF-kappaB pathway. Thirunavukkarasu PS, Prathaban P Dhanapalan P. An experimental trial with Phyllanthus amarus in lantana toxicity of calves. View abstract. Beneficial effects of Phyllanthus amarus for chronic hepatitis B, not confirmed. Treatment of chronic liver diseases with traditional Chinese medicine. View abstract. 2006;89(3):619-623. J Med Virol. Ajala, T. O., Igwilo, C. I., Oreagba, I. Nitnaware KM, Naik DG Nikam TD. Larvicidal activity of the essential oil from Phyllanthus amarus Sch. BJU Int. Hypoglycemic Effect of an Aqueous Extract of Phyllanthus sellowianus ("sarandi blanco") in C57BL/Ks mice. Stop using chanca piedra at least two weeks before a planned surgery. Munshi, A., Mehrotra, R., and Panda, S. K. Evaluation of Phyllanthus amarus and Phyllanthus maderaspatensis as agents for postexposure prophylaxis in neonatal duck hepatitis B virus infection. Indian Drugs 1993;30:338-341. N Z Med J 1994;107:243. 1995 Nov;33(11):861-4. Chanca piedra is one of the best-studied herbs to prevent kidney stones. If youre prone to stones, following a few simple solutions can help: 1. The comparative effects of methanol extract of Phyllanthus amarus leaves and Vitamin E on the sperm parameters of male guinea pigs. When eating oxalate-rich foods, eat or drink those rich in calcium. Micali, S., Sighinolfi, M. C., Celia, A., De, Stefani S., Grande, M., Cicero, A. F., and Bianchi, G. Can Phyllanthus niruri affect the efficacy of extracorporeal shock wave lithotripsy for renal stones? Obasi BN, Igboechi CA Anuforo DC et al.
Singh, M., Tiwari, N., Shanker, K., Verma, R. K., Gupta, A. K., and Gupta, M. M. Two new lignans from Phyllanthus amarus. Chanca piedra may increase the excretion of electrolytes like potassium. However, even if supplements are third-party tested, that doesn't mean they are safe for all or effective in general. J Ethnopharmacol. 2018 Jul-Aug; 44(4): 758764. Antiviral Res 2003;58(2):175-186. Taking chanca piedra along with other "water pills" might cause the body to lose too much water. While this effect can help manage hyperglycemia (high blood sugar) in animals, more human studies are needed. 2006;29(1):177-179. What should I eat to lower the risk of uric acid stones? Stay on the safe side and avoid use. 2006;7(2):299-302. Okoli CO et al. Ajaiyeoba E, Kingston D. Cytotoxicity evaluation and isolation of a chroman derivative from Phyllanthus amarus aerial part extract. Amli, Arranca-Pedras, Bhonya, Bhoomi Amalaki, Bhui-Amla, Bhumi Amla, Bhuianvalah, Bhuimy Amali, Bhuin Amla, Bhumy Amalaki, Bhumyamalaki, Brise Pierre, Cane Peas Senna, Cane Senna, Carry-Me-Seed, Casse-Pierre, Chancapiedra, Chanca-Piedra Blanca, Chance Pierre, Child Pick-a-Back, Creole Senna, Daun Marisan, Derriere-Dos, Des Dos, Deye Do, Dukong Anak, Elrageig, Elrigeg, Erva-Pombinha, Evatbimi, Feuilles la Fièvre, Gale-Wind Grass, Graine En Bas Fièvre, Graine-En-Bas-Feuille, Hurricane Weed, Jar-Amla, Jar Amla, Kizha Nelli, Malva-Pedra, Mapatan, Memeniran, Meniran, Niruri, Nymphanthus niruri, Para-Parai Mi, Paraparai Mi, Pei, Phyllanto, Phyllanthus amarus, Phyllanthus carolinianus, Phyllanthus fraternus, Phyllanthus kirganella, Phyllanthus lathyroides, Phyllanthus lonphali, Phyllanthus niruri, Phyllanthus sellowianus, Pierre de Chanca, Pitirishi, Pombinha, Punarnava, Quebra Pedra, Quebrapedra, Quinina Criolla, Quinine Creole, Quinine Weed, Rami Buah, Sacha Foster, Sasha Foster, Seed on the Leaf, Semence dans la Feuille, Shka-Nin-Du, Shatter Stone, Stone Breaker, Stone-Breaker, Stonebreaker, Tamalaka, Turi Hutan, Viernes Santo, Ya-Taibai, Yaa Tai Bai, Yah-Tai-Bai, Yerba de San Pablo. Always speak with a healthcare provider before taking a supplement to ensure that the supplement and dosage are appropriate for your individual needs. Indian J Pharmacol. Mellinger, C. G., Carbonero, E. R., Cipriani, T. R., Gorin, P. A., and Iacomini, M. Xylans from the medicinal herb Phyllanthus niruri. on five vegetative organisms. Integr.Cancer Ther. View abstract. Dhianawaty DD, Padmawinata K Soediro I et al. Ann.Trop.Med Parasitol. You are encouraged to report negative side effects of prescription drugs to the FDA. Raintree tropical plant database, Amazon plants. Please review the supplement label with your healthcare provider to discuss potential interactions with foods, other supplements, and medications. View abstract. In test-tube studies, chanca piedra extract has killed the bacterium Helicobacter pylori, which causes stomach ulcers. The effect of Phyllanthus niruri on urinary inhibitors of calcium oxalate crystallization and other factors associated with renal stone formation. 11-1-2007;114(2):169-173. View abstract. Bioefficacy of Tinospora cordifolia and Phyllanthus niruri plants against Spodoptera litura (Fabricius) and Dysdercus koenigii (Fabricius). vitamins, herbs, dietary supplements a-z listchanca piedra. Devika R, Sajitha U. Phytochemical and pharmacological investigation of Phyllanthus niruri - a preliminary screening. 2005;68(10):1479-1483. One of the earliest studies of chanca piedra found that people who drank a traditionally brewed tea for 1 to 3 months had a significantly reduced rate of kidney stones. 2010;48(1):396-401. More research in humans is needed to support these claims. Asian Pac.J Cancer Prev. View abstract. Indian J Pathol.Microbiol. 4-Methoxy-nor-Securinine, a New Alkaloid from Phyllanthus niruri. View abstract. www.ars-grin.gov/duke (Accessed 3 November 1999). extract in ethanol treated rats: in vitro and in vivo studies. Chanca piedra has been used for kidney stones, hepatitis B, and digestive health. A prospective, randomised short term study [abstract no: 178] . Kumar, K. B. and Kuttan, R. Chemoprotective activity of an extract of Phyllanthus amarus against cyclophosphamide induced toxicity in mice. Taking chanca piedra along with diabetes medications might cause your blood sugar to go too low. In a clinical trial involving kidney stones, chanca piedra demonstrated the same effect. View abstract. J Nat.Prod. Effect of phyllanthus niruri on metabolic parameters of patients with kidney stone: a perspective for disease prevention. Studies on the possible mechanisms of antidiabetic activity of extract of aerial parts of Phyllanthus niruri.
We've updated our Privacy Policy, which will go in to effect on September 1, 2022. There isn't enough evidence from clinical research to show a precise, safe, and effective dose of chanca piedra. Indian J Biochem Biophys. The plant grows in the Amazon rainforest and other tropical areas of the world. It Could Be Your Adrenals, Tame The Flames: 6 Anti-Inflammatory Supplements, Feeling Sluggish and Low on Energy? 2003 Feb;30(6):374-9. Integr.Cancer Ther. Zhang JL, He WN Ye P. Clinic observation on Phyllanthus amarus for treating chronic HBV infection. View abstract. Agri Res Svc: Dr. Duke's phytochemical and ethnobotanical databases. Immunol.Invest 2010;39(3):245-267. Chanca piedra lowered urinary oxalate and uric acid (waste products that exit your body via urine). Is it possible to reduce the risk of getting calcium oxalate stones? View abstract. Banerjee A, Chattopadhyay S. Effect of over-expression of Linum usitatissimum PINORESINOL LARICIRESINOL REDUCTASE (LuPLR) gene in transgenic Phyllanthus amarus. Journal of Applied Sciences and Environmental Management 2009;37-41. 2010;36(6):657-64. doi:10.1590/s1677-55382010000600002, Lee NY, Khoo WK, Adnan MA, Mahalingam TP, Fernandez AR, Jeevaratnam K. The pharmacological potential of Phyllanthus niruri. Nworu, C. S., Akah, P. A., Okoye, F. B., and Esimone, C. O. Aqueous extract of Phyllanthus niruri (Euphorbiaceae) enhances the phenotypic and functional maturation of bone marrow-derived dendritic cells and their antigen-presentation function. Narendranathan, M., Remla, A., Mini, P. C., and Satheesh, P. A trial of Phyllanthus amarus in acute viral hepatitis. - an hepatoprotective plant. Luyindula, N, Tona, L, Lunkebila, S, Cimanga, RK, Vlietinck, AJ, and et al. View abstract. And senna and aloe contain anthraquinones, compounds that bind calcium and reduce the growth rate of urinary crystals. Murugaiyah, V. and Chan, K. L. Analysis of lignans from Phyllanthus niruri L. in plasma using a simple HPLC method with fluorescence detection and its application in a pharmacokinetic study. Planta Med 1991;57(1):98. Mazumder A, Mahato A Pattnaik AK et al. View abstract. View abstract. Histological effects of chronic administration of Phyllanthus amarus on the superior colliculus of adult wistar rats. Colombo, R., de, L. Batista AN, Teles, H. L., Silva, G. H., Bomfim, G. C., Burgos, R. C., Cavalheiro, A. J., da, Silva Bolzani, V, Silva, D. H., Pelicia, C. R., Guimaraes, F. M., and Heimberg, M. C. Validated HPLC method for the standardization of Phyllanthus niruri (herb and commercial extracts) using corilagin as a phytochemical marker. One health benefit of chanca piedra is that its antioxidants may improve fasting blood sugar levels in certain animals. Cancer Lett. Dosage: How Much Chanca Piedra Should I Take? There may be a disruption in electrolyte balance if too much chanca piedra is taken. Increase insulin activity by Phyllanthus amarus Linn on liver cell regeneration in partially hepatectomised albino rats. 10-8-2003;478(2-3):145-153. Journal of Natural Remedies 2001;1(1):55-59. Biomedical & Pharmacology 2010;123-128. Effect of extract of Phyllanthus niruri on crystal deposition in experimental urolithiasis.
Alvari A, Rafsanjani MS Ahmed FJ et al. African Journal of Biotechnology 2007;728-731. Kidney Stones: Treatment. Herbs of the genus Phyllanthus in the treatment of chronic hepatitis B: observations with three preparations from different geographic sites. When taken with water pills, chanca piedra could cause your blood pressure to be too low.Lithium: Chanca piedra may act as a diuretic (water pill), impacting how efficiently the body gets rid of lithium. View abstract. & Thonn. To prevent uric acid kidney stones, reduce the amount of meat, eggs, fish, and poultry you eat.
J Ethnopharmacol. Journal of Experimental Zoology 2003;6(1):151-156. View abstract. Antidiabetic medications (including insulin and oral medications such as DiaBeta, and Diabinese): Chanca piedra is thought to lower blood sugar levels. Journal of Essential Oil Research 2009;393-399. B., Antarkar, D. S., Deolalikar, R., and Antani, D. H. A two-stage clinical trial of Phyllanthus amarus in hepatitis B carriers: failure to eradicate the surface antigen.
In vitro study on alpha-amylase inhibitory activity of an Indian medicinal plant, Phyllanthus amarus. Faremi, T. Y., Suru, S. M., Fafunso, M. A., and Obioha, U. E. Hepatoprotective potentials of Phyllanthusamarus against ethanol-induced oxidative stress in rats. Wang LT, He Y Ren JW Jiang J et al. Annals of Biological Research 2011;298-305. Lancet 10-1-1988;2(8614):764-766. Abdulla MA, Ahmed KA Al-Bayaty FH et al. Phytochemistry 1996;43(3):715-717. View abstract. Journal of Applied Sciences and Environmental Management 2009;5-9. Asian Journal of Biotechnology 2009;154-162. 7-15-2009;124(2):233-239. Fitoterapia 1993;64(3):235-238. New seco- and hydroxy-lignans from Phyllanthus niruri. Soares LA, Bassani VL Ortega GG et al. Manjrekar, A. P., Jisha, V., Bag, P. P., Adhikary, B., Pai, M. M., Hegde, A., and Nandini, M. Effect of Phyllanthus niruri Linn. Avoid foods high in oxalates, compounds that occur naturally in many foods and are the basis for many kidney stones. For this reason, it's difficult for researchers to recommend one proper dosage to ensure safety and effectiveness. Biol.Pharm.Bull. Rapid RP-HPLC technique for the determination of phyllanthin as bulk and its quantification in Phyllanthus amarus extract. Phytochemistry 2008;69(3):759-764.
Ishimaru K, Yoshimatsu K Yamakawa T et al. Follow the package instructions for when to discard the supplement as well. View abstract. Akinnibosun, FJ Akinnibosun HA Ibeh IN et al.
Ali, H., Houghton, P. J., and Soumyanath, A. alpha-Amylase inhibitory activity of some Malaysian plants used to treat diabetes; with particular reference to Phyllanthus amarus. Innovative Food Science & Emerging Technologies 2010;526-532. Myanmar Health Sciences Research Journal 2009;17-21. Animal studies show that chanca piedra supplements may decrease uric acid levels in humans. et Thonn (Euphorbiaceae) against three species of mosquitoes. Chem Pharm.Bull. Eliminate refined sugar and high fructose corn syrup. Berk, L., de Man, R. A., Schalm, S. W., Labadie, R. P., and Heijtink, R. A. Excessive excretion of potassium can decrease potassium to unsafe levels, causing an electrolyte imbalance. Rajeshkumar, N. V., Joy, K. L., Kuttan, G., Ramsewak, R. S., Nair, M. G., and Kuttan, R. Antitumour and anticarcinogenic activity of Phyllanthus amarus extract. Krithika, R. and Verma, R. J. Ameliorative potential of Phyllanthus amarus against carbon tetrachloride-induced hepatotoxicity. In addition to the uses listed above, other traditional uses for chanca piedra include: However, studies haven't produced the kind of high-quality evidence needed to validate any digestive health claims at this time. and its protective mechanism on paracetamol hepatotoxicity in rats. Chemosphere 2005;61(11):1644-1650. Brook, M. G. Effect of Phyllanthus amarus on chronic carriers of hepatitis B virus. Chanca piedra is known by several names, including: The herb contains phytochemicals that may increase urine flow, destroy harmful bacteria and viruses, and reduce inflammation. 2005;12(6-7):494-500. Southeast Asian J Trop.Med Public Health 2007;38(4):609-615. Harvard Health Publication. View abstract. Vijayanand V, Nagarajan B Vasu K. Efficacy of Azadirachta indica and Phyllanthus amarus in experimental hepatitis in dogs. Molecular Medicine & Advance Sciences 2006;184-189. Studies on the possible mechanisms of antidiabetic activity of extract of aerial parts of Phyllanthus niruri. Zhu FM, Zhang JQ Zhang XZ et al. Barros, M. E., Lima, R., Mercuri, L. P., Matos, J. R., Schor, N., and Boim, M. A. National Institutes of Health. Evaluation of the levels of the lignans phyllanthin, hypophyllanthin and niranthin in "quebra-pedra" (Phyllanthus amarus Schumach. J-Clin-Epidemiol 1997;50(8S). Chanca piedra has been used for thousands of years to relieve pain, reduce muscle spasms and block inflammation. Taesotikul, T., Dumrongsakulchai, W., Wattanachai, N., Navinpipat, V., Somanabandhu, A., Tassaneeyakul, W., and Tassaneeyakul, W. Inhibitory effects of Phyllanthus amarus and its major lignans on human microsomal cytochrome P450 activities: evidence for CYP3A4 mechanism-based inhibition. Teratog.Carcinog.Mutagen. Pharmaceutical Biology 2006;44:668-671. Adeneye AA, Benebo AS Agbaje EO. Therapeutic observation of Phyllanthus amarus for treatment of hepatitis B . Freitas AM et al. Thidiazuron-induced shoot organogenesis and production of hepatoprotective lignan phyllanthin and hypophyllanthin in Phyllanthus amarus. under water deficit conditions. J Pharm Pharmacol. Food Chemistry 2009;1405-1412. The Anti-Inflammatory and Antinociceptive Properties of the Chloroform Fraction From Phyllanthus niruri Plant Is Mediated via the Peripheral Nervous System. View abstract. McHarg T et al. If theyre small enough, kidney stones can pass through the urinary tract on their own with no incident, but larger ones can cause enormous pain and serious complications. 2010 Jun;101(12):4676-89. Bionotes 2011;14-16. Venkateswaran, P. S., Millman, I., and Blumberg, B. S. Effects of an extract from Phyllanthus niruri on hepatitis B and woodchuck hepatitis viruses: in vitro and in vivo studies. View abstract. Andrew EO, Enogieru A. Chanca piedra may have interactions with herbal supplements exhibiting the same effects listed above, such as: It is essential to read the labels of supplements. Indian J Med Sci 2003;57(9):387-393.
Thyagarajan, S. P., Jayaram, S., Valliammai, T., Madanagopalan, N., Pal, V. G., and Jayaraman, K. Phyllanthus amarus and hepatitis B. Lancet 10-13-1990;336(8720):949-950. View abstract. 2008;13(5):199-207. Preventive effect of Phyllanthus amarus on prostatic hyperplasia. Exploring alternative treatments for Helicobacter pylori infection, Studies on the possible mechanisms of antidiabetic activity of extract of aerial parts of Phyllanthus niruri, Eating, diet, and nutrition for kidney stones, The kidney stone diet: Not as restricive as you may think, Infections (including sexually transmitted infections). Asian Journal of Experimental Sciences 2010; Bhattacharjee, R. and Sil, P. C. Protein Isolate from the Herb Phyllanthus niruri Modulates Carbon Tetrachloride-Induced Cytotoxicity in Hepatocytes. A 2014 study found that chanca piedra had antimicrobial activity (the ability to kill or prevent microbes) against Helicobacter pylori (H. pylori). 2011;22(4):361-366. 2014 Nov 28:1-22. Iizuka, T., Moriyama, H., and Nagai, M. Vasorelaxant effects of methyl brevifolincarboxylate from the leaves of Phyllanthus niruri. vitamins, herbs, dietary supplements a-z list. et Thonn. Londhe, J. S., Devasagayam, T. P., Foo, L. Y., and Ghaskadbi, S. S. Antioxidant activity of some polyphenol constituents of the medicinal plant Phyllanthus amarus Linn. Antibacterial effect of Phyllanthus niruri (Chanca Piedra) on three enteropathogens in man. Norepinephrine treats low blood pressure by causing blood vessels to constrict. Acta Pol.Pharm. Clinic study on chronic HBV infection treated by Phyllanthus amarus. Evaluation of antiinflammatory activity of methanol extract of Phyllanthus amarus in experimental animal models. L.Acta Farmaceutica Bonaerense 2003;33:203-207. As with all supplements and plant medicines, it's essential to discuss the use of chanca piedra with your healthcare provider before taking it. View abstract. By clicking Accept All Cookies, you agree to the storing of cookies on your device to enhance site navigation, analyze site usage, and assist in our marketing efforts. Indian J Exp.Biol. Int Braz J Urol. J Hepatol. J Ethnopharmacol. Journal of Medicinal and Aromatic Plant Sciences 1999;21(1):51. Houghton PJ, Woldemariam TZ O'Shea S et al. It was pointed out that these are also symptoms of kidney stones. Immunopharmacol.Immunotoxicol. A. and Benebo, A. S. Protective effect of the aqueous leaf and seed extract of Phyllanthus amarus on gentamicin and acetaminophen-induced nephrotoxic rats. View abstract. Plant Archives 2008;563-568. & Thonn.--a hepatoprotective herb. Side effects reported in one human study using a chanca piedra infusion included: Additional health risks of chanca piedra may include: Chanca piedra may lower blood sugar levels, which means it might affect blood sugar control during and after surgery. Next to red peppers, you can get the most vitamin C from ________________. Myint MM, Than MA Lwin KK et al. The pharmacological potential of Phyllanthus Niruri. 2006;29(7):1310-1313. BJU.Int. Vaccine 1990;8 Suppl:S86-S92. Etta HE, Udoh PB Asuquo BO et al. Srividya N et al. 2011;30(1):43-53. Murali B, Amit A Anand MS et al. Obidike IC, Salawu OA Ndukuba M et al. View abstract. International Journal of Phytomedicine 2011;115-119. Teramoto JR, Oliveira RF Santos AS et al.
Phytother.Res 2006;20(7):595-601. Chanca piedra supplements are available in powder, juice, or tea form. Thyagarajan, S. P., Subramanian, S., Thirunalasundari, T., Venkateswaran, P. S., and Blumberg, B. S. Effect of Phyllanthus amarus on chronic carriers of hepatitis B virus. This conversation is especially important if you have a health condition or are taking any medications, other plant medicines, or dietary supplements. Antimicrobial activity of an Amazon medicinal plant (Chancapiedra) (Phyllanthus niruri L.) against Helicobacter pylori and lactic acid bacteria. Fitoterapia 2006;77(7-8):511-514. Inositol hexaphosphate, a carbohydrate found in cereal grains, beans, brown rice and other high-fiber foods helps reduce urinary calcium levels, inhibit crystallization of calcium salts, and lower the risk of stones. Toxicol.Mech.Methods 2010;20(8):498-503. J Nat.Prod. 2017 Jul; 9(7): 766. View abstract. Boim, M. A., Heilberg, I. P., and Schor, N. Phyllanthus niruri as a promising alternative treatment for nephrolithiasis. View abstract. Pharm Biol. These agencies evaluate products and report on herbal and natural products' safety, purity, and potency. Sumathi, P Parvathi A. Antibacterial potential of Phyllanthus niruri L. Journal of Pure and Applied Microbiology 2011;425-428. Akin-Osanaiye CB, Gabriel AF Alebiosu RA. View abstract. Bhattacharjee, R. and Sil, P. C. The protein fraction of Phyllanthus niruri plays a protective role against acetaminophen induced hepatic disorder via its antioxidant properties. Kiemer, A. K., Hartung, T., Huber, C., and Vollmar, A. M. Phyllanthus amarus has anti-inflammatory potential by inhibition of iNOS, COX-2, and cytokines via the NF-kappaB pathway. Thirunavukkarasu PS, Prathaban P Dhanapalan P. An experimental trial with Phyllanthus amarus in lantana toxicity of calves. View abstract. Beneficial effects of Phyllanthus amarus for chronic hepatitis B, not confirmed. Treatment of chronic liver diseases with traditional Chinese medicine. View abstract. 2006;89(3):619-623. J Med Virol. Ajala, T. O., Igwilo, C. I., Oreagba, I. Nitnaware KM, Naik DG Nikam TD. Larvicidal activity of the essential oil from Phyllanthus amarus Sch. BJU Int. Hypoglycemic Effect of an Aqueous Extract of Phyllanthus sellowianus ("sarandi blanco") in C57BL/Ks mice. Stop using chanca piedra at least two weeks before a planned surgery. Munshi, A., Mehrotra, R., and Panda, S. K. Evaluation of Phyllanthus amarus and Phyllanthus maderaspatensis as agents for postexposure prophylaxis in neonatal duck hepatitis B virus infection. Indian Drugs 1993;30:338-341. N Z Med J 1994;107:243. 1995 Nov;33(11):861-4. Chanca piedra is one of the best-studied herbs to prevent kidney stones. If youre prone to stones, following a few simple solutions can help: 1. The comparative effects of methanol extract of Phyllanthus amarus leaves and Vitamin E on the sperm parameters of male guinea pigs. When eating oxalate-rich foods, eat or drink those rich in calcium. Micali, S., Sighinolfi, M. C., Celia, A., De, Stefani S., Grande, M., Cicero, A. F., and Bianchi, G. Can Phyllanthus niruri affect the efficacy of extracorporeal shock wave lithotripsy for renal stones? Obasi BN, Igboechi CA Anuforo DC et al.
