(8) (9). Topical niacinamide has been studied alone and in combination with calcipotriene for the treatment of patients with psoriasis. Bissett DL, Oblong JE, Saud A, et al. This wonder ingredient works in treating almost any skin issue. Niacinamide inhibits protein glycation effectively reducing deposition of cross-linked collagen and elastin molecules in the skin. If it didnt go well with niacinamide, we wouldnt have had so many studies highlighting its benefits. But is there any science behind those claims? The .gov means its official. That said, oral and topical niacinamide may have some actual benefits for skin health: Ask a dermatologist what niacinamide does best, and the very first niacinamide benefit theyll list is probably skin cancer prevention. In a 2015 study in the New England Journal of Medicine, researchers gave 386 patients 500 mg of oral niacinamide or a placebo twice daily for a whole year. SELF may earn a portion of sales from products that are purchased through our site as part of our Affiliate Partnerships with retailers. These electrons scavenge through your body, damaging your DNA and other important components. The results do not apply to other patient populations. This is welcome news. ", The British journal dermatology: Nicotinamide increases biosynthesis of ceramides as well as other stratum corneum lipids to improve the epidermal permeability barrier., The Journal of Nutritional Biochemistry: The anti-inflammatory and antioxidative effects of nicotinamide, a vitamin B (3) derivative, are elicited by FoxO3 in human gestational tissues: implications for preterm birth., The New England Journal of Medicine: A Phase 3 Randomized Trial of Nicotinamide for Skin-Cancer Chemoprevention., University of Michigan Medical School: The Role of Nicotinamide in Acne Treatment., Wiley Online Library: Topical 4% nicotinamide vs. 1% clindamycin in moderate inflammatory acne vulgaris, Topical niacinamide reduces yellowing, wrinkling, red blotchiness, and hyperpigmented spots in aging facial skin.. Thus it is not surprising that topical application of niacinamide reduces skin sallowness. Niacinamide also reduces facial sebum production making it a valuable ingredient for patients who desire skin rejuvenation, but may be acne-prone. 
Nicotinamide has been used in combination with tetracycline for treating bullous pemphigoid. Which ingredients can you combine with niacinamide? In the New England Journal of Medicine, a 2015 study showed that one of the things that niacinamide may do best is preventing skin cancer.
Niacinamide is also used in various skin lightening creams and serums. The other one is nicotinic acid. If you arent quite sure what niacinamide is or what its doing in your moisturizer, youre not alone. The anti-inflammatory properties in this nutrient make it an ideal treatment for skin inflammation.. Skin sallowness seen in actinically damaged skin is believed to be a result of glycated cross-linked yellow-brown proteins that accumulate in the skin after sun exposure. This results in premature skin aging. The pillthe vitamin B3 supplement called nicotinamidecut the rate of new squamous-cell and basal-cell skin cancers by 23% compared with placebo after 1 year among patients at high risk for skin cancer. An official website of the United States government. 1. https://www.ncbi.nlm.nih.gov/pubmed/16029679, 2. https://www.ncbi.nlm.nih.gov/pubmed/17147561, 3. https://www.ncbi.nlm.nih.gov/pubmed/12100180, 4. https://www.ncbi.nlm.nih.gov/pubmed/17147561, 5. https://www.ncbi.nlm.nih.gov/pubmed/17147561, 6. https://www.ncbi.nlm.nih.gov/pubmed/28681504, 7. https://www.ncbi.nlm.nih.gov/pubmed/28321860, 8. https://www.ncbi.nlm.nih.gov/pubmed/16871774, 9. https://www.ncbi.nlm.nih.gov/pubmed/12558633, 10.https://www.sciencedirect.com/science/article/abs/pii/S0022354915336042?via%3Dihub. Niacinamide creams or gels can be used at night before you sleep. Skinkraft uses cookies or similar technologies to offer you a better experience and analyze insights into user behaviour. Oral and topical niacinamide have been shown to reduce UV-induced immunosuppression. The authors suggest that topical niacinamide may provide additional benefits and be useful as a steroid-sparing substitute.
Studies suggest that niacinamide when used in 5% concentrations, can lighten dark spots and treat hyperpigmentation by blocking the transfer of melanocytes (pigment-forming cells) to the skin surface. Cutis: Pharmacologic doses of nicotinamide in the treatment of inflammatory skin conditions: a review., Dermato Endocrinology: Hyaluronic acid: A key molecule in skin aging., Hindawi: A Double-Blind, Randomized Clinical Trial of Niacinamide 4% versus Hydroquinone 4% in the Treatment of Melasma., International Journal of Cancer: Niacin intake and risk of skin cancer in US women and men., Journal of Biomedicine and Biotechnology: Depigmenting Effect of Kojic Acid Esters in Hyperpigmented B16F1 Melanoma Cells., Journal of Cosmetic Dermatology: Nicotinic acid/niacinamide and the skin., Journal of Nucleic Acids: Role of Nicotinamide in DNA Damage, Mutagenesis, and DNA Repair., Journal of the American Academy of Dermatology: Ability of topical 5% niacinamide to reduce ultraviolet light-induced erythema, barrier disruption, and inflammation. Your skin has a protective barrier that prevents water loss and external aggressors from entering. 2005 - 2022 WebMD LLC. The participants in the study had a history of skin cancer, but the nutrient's effects on the general public are not known yet. If you're considering using niacinamide to treat hyperpigmentation and dark spots, its best to combine it with other ingredients. Disclosures: Dr. Farris is a consultant to LOreal. Oral niacinamide reduces the onset of actinic keratosis, indicating that this vitamin may be helpful in reducing more terminal forms of photoaging including skin cancer formation. What Is The Difference Between Niacinamide And Niacin? 
SELF does not provide medical advice, diagnosis, or treatment. Tea tree oil: What can it do for your patients. It is a precursor for co-factors NAD(H)and NADP(H) that are important in a variety of cellular pathways that affect skin physiology. Research on the benefits of niacinamide to your skin is still in its early stages, but topical niacinamide contains properties that help treat some skin conditions like acne and eczema. You might see niacinamide pop up in a topical product and in supplement form (well explain the differences between the two and any potential side effects below) and wonder which one to choose. Studies have demonstrated that topical application of niacinamide reduces skin sensitivity to irritating surfactants such as sodium laurel sulfate (SLS) and can be used to improve the tolerability of ingredients such as retinoids. Greatens A, et al. It makes for an attractive treatment option for people with sensitive or dry skin. In other (less confusing) words, the ability to potentially help your body create more NAD+ and, therefore, repair damage is thought to be the root of niacinamides potential skin-care benefits in both topical and even potentially supplement form. Any information published on this website or by this brand is not intended as a substitute for medical advice, and you should not take any action before consulting with a healthcare professional. The 58 Best Drugstore Beauty Buys Under $20, All the Amazon Prime Day Skin-Care Deals to Score Before Midnight. Vitamin B3 derivatives provide numerous anti-aging benefits. The patients were checked by a dermatologist every 3 months and suspicious lesions were biopsied. 6. Heres what you should know about niacinamide benefitsand how to use niacinamidebefore adding it to your skin-care routine. Limited evidence also shows that topical niacinamide works to repair the function of the outer protective skin layer. 
The Natural Food Sources of Vitamin B3 Are: Niacinamide is a powerhouse in itself. The anti-inflammatory properties of niacinamide are also beneficial for acne-prone skin, especially in those patients with papules and pustules. Arch Dermatol.
The investigators are from Australia, which has extremely high rates of sun-induced skin cancers. Niacinamide also helps prevent the transfer of pigment within the skin, meaning that you'll have fewer brown spots. 2022 Cond Nast. Some dermatologists feel that topical niacinamide is overall more effective. And it doesnt tell us anything about using niacinamide to help prevent melanoma skin cancers (and the research we do have suggests its more helpful for preventing squamous cell carcinoma).4 But if youve had multiple non-melanoma skin cancers in your life, you should ask your dermatologist about oral niacinamide. about navigating our updated article layout. Niacinamide, which is also called nicotinamide, is a form of vitamin B3 (niacin) found in supplements, skin-care products, and food. In one study in the International Journal of Dermatology, a topical mixture of 4% of the nutrient was as effective as 1% clindamycin in acne treatment. 1994;130960;753-758, 3. Cosmeceuticals contain three primary forms of vitamin B3 including niacinamide, nicotinic acid and nicotinate esters. Niacinamide is a form of Vitamin B3, which enriches your body with two important molecules: NAD+ and NADP+. However, it comes with its share of side effects that include skin irritation and dryness. will also be available for a limited time. We found NuFace, Charlotte Tilbury, Kiehl's, Paulas Choice, and more. Both of these molecules are central to the chemical reactions that your cellsincluding skin cellsneed to repair damage, reproduce, and function normally. This is a new opportunity for skin cancer prevention, said lead investigator Diona Damian, MBBS, PhD, Professor of Dermatology, Dermatology University of Sydney, New South Wales, Australia. Topical niacinamide repairs the broken barrier and prevents moisture loss, keeping the skin soft and hydrated. But is topical niacinamide helpful too? That said, people with allergic tendencies may experience a flushing reaction due to histamine release. Niacinamide readily penetrates the stratum corneum and has a favorable tolerability profile, as it does not cause cutaneous irritation or flushing commonly seen with nicotinic acid. Although it is usually safe to use it every day, apply topical niacinamide as recommended by your doctor. Perspectives on Advanced Basal Cell Carcinoma, Innovations in the Treatment of Atopic Dermatitis, Perspectives on Generalized Pustular Psoriasis, Examinations of Dupilumab Efficacy Across Various Patient Types and Anatomic Areas in the Management of Atopic Dermatitis, Society of Dermatology Nurse Practitioners. Other studies show that a 5% concentration of niacinamide benefits hyperpigmentation after potentially just four weeks.11. All of the participants had at least two non-melanoma skin cancers within the previous five years and, therefore, were at a high risk for developing another skin cancer. A previous phase 2 study by this group showed that nicotinamide reduced the number of new actinic keratoses in Australian patients with sun-damaged skin. The new PMC design is here! Most major studies that weve cited here used topical preparations containing 2-10% niacinamide, so look for a product in that range if you canDr. Some people experience some mild irritation, which will likely go away with repeated use. The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer. The benefits of coconut, argan, tea tree and more. One of the unique benefits of niacinamide as an anti-aging ingredient is that it enhances barrier function.
The study focused on people who had experienced skin cancer beforenot the general public. You can use niacinamide in your skin-care routine on a long-term basis, specifically if youre using it for anti-aging concerns, Dr. Amin says. Although the mechanisms in play remain to be elucidated, in vitro studies suggest that niacinamide increases dermal collagen production while at the same time reducing excess dermal glycosaminoglycan production. Sometimes, this barrier can break, courtesy alkaline-based products, harsh chemicals, dry climates and other factors. and transmitted securely. The pill does not take the place of sunscreen use and regular skin checkups by dermatologists for people at high risk, Dr Damian noted. This doesnt mean that two niacinamide capsules a day (which is what participants took in the study) will stave off skin cancer forever, though. If youre looking for a moisturizer with niacinamide, you may want to check out CeraVe PM Face Moisturizer ($16), and Dr. Zampella also recommends The Ordinary Niacinamide 10% + Zinc 1% serum ($6). The Truth: Studies suggest that niacinamide, combined with any acid, can partially convert into niacin only under high temperatures. The investigators emphasized that these results were achieved in individuals who previously had skin cancer and were thus at high risk for new skin cancers. This preventive treatment has no side effects. The site is secure. Niacinamide can be used to improve a variety of clinical stigmata seen in photoaging. Overall, you'll have stronger skin that preserves hydration for improved skin health., PreventsSkin Cancer. Note: No matter what your skin type is, it is always better to conduct a patch test before applying the product to your face. Present in most of the effective skincare products, Niacinamide has gained so much popularity because it can be used to treat almost every skin issue and is suitable for all skin types. If you don't see any results within a few months, consult with your skincare specialist. (Of course, an effective acne regimen is unique to each person, so its probably best, if youre able, to see a board-certified dermatologist to figure out what makes sense for you.) NADH and NADPH decrease with age giving rise to the notion that supplementing skin with niacinamide can provide anti-aging benefits. Anything more than that may cause skin irritation and should be used in targeted areas only. Ad Choices, The Potential Niacinamide Benefits You Should Know About, I Was Diagnosed With Monkeypox and the Symptoms Are Pretty Brutal, How to Keep Your Vagina Healthy During Swimsuit Season, Here Are the Side Effects You May Experience After the Monkeypox Vaccine. 5. There isnt a prescription version of topical niacinamide, but your dermatologist may be able to add it to topical prescriptions in a process called compounding. Niacinamide is used to treat a host of other issues related to your body and skin. NADPH is a cofactor for the synthesis of fatty acids and lipids, such as ceramides, that are crucial for epidermal barrier function. It also improves skin elasticity. In addition, niacinamide increases the production of proteins such as keratin, involucrin and filaggrin that are important factors in the formation and maintenance of the cornified envelop (or outermost layer of the skin). While theres no current research specifically on niacinamides effectiveness in general on melanin-rich skin, its likely that it would be able to reduce sun damage and dark spots because of its ability to reduce melanin production, Dr. Amin says.Another split-face study, this one published in 2011 in Dermatology Research and Practice, found that a topical 4% niacinamide treatment was effective for treating melasma over eight weeks in 27 participants. It is found in foods like yeast, fish, milk, eggs, grains and vegetables. Use of this site constitutes acceptance of our User Agreement and Privacy Policy and Cookie Statement and Your California Privacy Rights.